Regression of corneal blood vessels in limbal stem cell deficiency
If you have any partnering opportunities for Regener8 members, please contact us.
NESCI would be interested in funding / studentship opportunities for the following proposal.
NESCI are interested in industrial partners who may like to collaborate in one of these fields (for a CASE studentship or other awards), or in anyone who is interested in these areas of research (including other academic groups). For further details, please contact Helen Clamp from NESCI.
Project: Regression of corneal blood vessels in limbal stem cell deficiency
Lead: Dr Sajjad Ahmad
The cornea is the clear front of the eye and its clarity is vital for normal visual functioning. The cornea is covered by an epithelium which is renewed by stem cells located at the periphery of the cornea, in a region known as the limbus. A deficiency of these so-called limbal stem cells results in the painful and blinding disease of limbal stem cell deficiency. One of the characteristics of this disease is the presence of new blood vessels on a normally avascular cornea. The use of anti-angiogenic agents to eliminate these corneal blood vessels will be invesigated using a mouse model of limbal stem cell deficiency. These studies will eventually result in the setting up of multi-centre trials in patients with limbal stem cell deficiency.
