Projects
3D Skin Constructs
Platform Technology for Robust Growth of Three Dimensional Skin Constructs In Vitro
Lead N8 Academic: Dr Stefan Przyborski, Durham
A partnership between: Reinnervate Ltd; and Biological Sciences, Durham University
Reinnervate specialises in the development and commercialisation of technology to enhance the growth, differentiation and function of cultured cells, especially stem cells and the formation of differentiated tissues. Its enabling technologies have multiple applications in the cell culture field for use in both the academic and industrial sectors. The Company has developed and patented novel technology that enables the routine growth of cells in three dimensions (3D). Preliminary work has demonstrated that progenitor cells derived from skin and cultured on these scaffolds form constructs resembling the structure of native skin.
In this project, the Company has formed collaborations with scientists at Durham University to further develop and characterise the skin construct, in preparation for its launch as a biological assay for use in skin epidermal barrier function tests. The project includes optimisation of the artificial skin, assessment and validation of the construct and demonstration of its function as an epidermal barrier.
The work will be supported by an experienced technician and managed by a project team including the academics interacting with Company management. The proposed work will produce a novel in vitro model for which there is demand in the healthcare and pharmaceutical industries. As a research tool tailored for routine use in high throughput applications, it will cater for current market demands and provide opportunities for new applications in basic research and pre-clinical investigation.
