Projects
Novel Bio-Processing
Optimisation and Validation of a Novel Bio-Processing System for Cellular Therapies
Lead N8 Academic: Dr Mary Herbert, Newcastle
Newcastle University, Walker Safety Cabinets Ltd, Parker Hannifin Ltd: domnick hunter Industrial Division
Cellular therapies require safe and reproducible methods for cell culture.
Researchers at Newcastle university have developed a novel closed system to provide environmental control during laboratory processing of gametes and embryos for IVF. The system consists of a series of interlinked workstations which provide a controlled environment for incubation and open manipulation of cells. This new system has already significantly improved embryo viability and pregnancy rates. The system may also provide cost-effective controlled processing for a range of bio-manufacturing applications by providing grade A air quality without the need for a purpose built Grade B clean room.
The Aims:
The team will determine whether the new system developed for IVF can be adapted to other cell therapy applications. In particular a system will be developed for depleting oxygen in the work area which is believed to increase the genetic stability of stem cells.
The Team:
Mary Herbert is a Reader in Reproductive Biology at the University of Newcastle and Honorary Consultant Embryologist, Newcastle upon Tyne Hospitals NHS Foundation Trust with significant experience in IVF and ES cell derivation.
Walker Safety Cabinets Ltd design, manufacture and distribute Microbiological Safety Cabinets, Laminar Flow workstations and clean rooms.
Parker Hannifin Ltd: domnick hunter Industrial Division manufacture and distribute a range of laboratory gas generators
